| A pilot study of the phase angle between cortisol and melatonin in major depression - a potential biomarker? | |
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MedLine Citation:
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PMID: 20004915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Hypothalamic-pituitary-adrenal (HPA) axis and melatonin rhythm alterations have been independently reported in major depression (MDD) as well as in insomnia. In this pilot study, we link cortisol and melatonin rhythms and propose that the phase angle between cortisol acrophase (CA) and dim-light melatonin onset (20 pg/ml) (DLMO-20) may yield a useful state specific biomarker for MDD. METHODS: Six healthy (HC) and six depressed (MDD) psychotropic free subjects were admitted to the General Clinical Research Center. Blood was sampled for cortisol and melatonin from 1600h to 1000h, under dim lights (<20lux) and constant routine. Time for DLMO-20 and peak cortisol concentration was determined for each subject. Phase angle was computed as the difference in time between CA and DLMO-20. RESULTS: Phase angle was significantly increased in MDD's versus HC's (13.40+/-1.61h. versus 11.61+/-1.66h, p=0.026). Using ROC analysis, a phase angle greater than 13.57h distinguished MDD's from HC's (sensitivity=0.83, specificity=1.0). Mean nocturnal melatonin (1600-1000h) was significantly decreased in MDD's versus HC's (22.67+/-9.08 pg/ml versus 47.82+/-14.76 pg/ml, p=0.015). CONCLUSIONS: The phase angle between CA and DLMO-20 appears to distinguish HC's from MDD's and may be a useful biomarker to aid biologic assessment as well as treatment. Lower nocturnal melatonin in MDD's highlights its importance in MDD's pathophysiology. Additional study with larger sample size is needed to confirm the results of this pilot study. The mechanism for this phase angle difference and decreased melatonin, itself, requires further study. |
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Authors:
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Theresa M Buckley; Alan F Schatzberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-12-11 |
Journal Detail:
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Title: Journal of psychiatric research Volume: 44 ISSN: 1879-1379 ISO Abbreviation: J Psychiatr Res Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376331 Medline TA: J Psychiatr Res Country: England |
Other Details:
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Languages: eng Pagination: 69-74 Citation Subset: IM |
Copyright Information:
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Copyright 2009. Published by Elsevier Ltd. |
Affiliation:
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Dept. of Psychiatry and Behavioral Sciences, Stanford University Medical School, 401 Quarry Road, Stanford, CA 94305-5730, United States. tbuckley@stanfordalumni.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Circadian Rhythm* Cross-Sectional Studies Depressive Disorder, Major / blood* Female Humans Hydrocortisone / blood* Male Melatonin / blood* Middle Aged Pilot Projects ROC Curve Time Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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2 M01 RR000070/RR/NCRR NIH HHS; 50604//PHS HHS; 5T32MH19938/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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