| A pilot study of leukocytapheresis efficacy with 1.5 liter blood processing volume in patients with ulcerative colitis. | |
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MedLine Citation:
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PMID: 18937719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Standard leukocytapheresis (LCAP) protocols recommend the processing of a 3 L blood volume. In this study, we evaluated the clinical effects of LCAP with 1.5 L of blood processing (1.5L-LCAP) in patients with active ulcerative colitis (UC). Ten patients with moderate to severe UC were enrolled. Their clinical and endoscopic responses, the kinetics of the peripheral blood counts and cytokine responses were evaluated. Clinical and endoscopic effects were assessed using the clinical activity index described by Rachmilewitz, and by Matts' endoscopic classification, respectively. The 1.5L-LCAP induced clinical remission in 8 out of 10 patients (80%). Endoscopic improvement was noted in 6 out of 7 patients (85.7%). Prednisolone (PSL) was used in 8 patients; the PSL dose could be reduced in 6 patients, and weaning was possible in one patient. Adverse effects were not observed during 1.5L-LCAP therapy. During the 1.5L-LCAP session, the leukocyte count reached the minimum at 1.0 L of blood processing, but promptly increased after completion of the session, and reached a maximum after 30 min. Interleukin (IL)-1beta-induced IL-8 and IL-6 secretion by peripheral blood mononuclear cells were both significantly reduced by 1.5L-LCAP therapy. 1.5L-LCAP was clinically effective for active UC patients. Cellular responses induced by 1.5L-LCAP were similar to those induced by a standard LCAP session. |
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Authors:
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Masaaki Shimada; Hiroaki Iwase; Tomoyuki Tsuzuki; Noboru Hirashima; Kyoko Kobayashi; Yusuke Hibino; Hisanori Watanabe; Nobumitsu Ryuge; Takafumi Ando; Hidemi Goto; Yuhki Yagi; Tomoyuki Tsujikawa; Akira Andoh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 12 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 368-73 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, National Hospital Organization, Nagoya Medical Center, Nagoya University Graduate School of Medicine, Nagoya, Japan. shimada@nnh.hosp.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Volume* Colitis, Ulcerative / blood, diagnosis*, therapy* Colonoscopy / methods Cytokines / metabolism* Female Follow-Up Studies Humans Inflammation Mediators / metabolism Leukapheresis / methods* Male Middle Aged Pilot Projects Probability Prospective Studies Remission Induction / methods Risk Assessment Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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