Document Detail


A pilot study: the importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome.
MedLine Citation:
PMID:  24211595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inorganic arsenic (iAs) exposure is detrimental to birth outcome. We lack information regarding the potential for iAs metabolism to affect fetal growth. Our pilot study evaluated postpartum Romanian women with known birth weight outcome for differences in iAs metabolism. Subjects were chronically exposed to low-to-moderate drinking water iAs. We analyzed well water, arsenic metabolites in urine, and toenail arsenic. Urine iAs and metabolites, toenail iAs, and secondary methylation efficiency increased as an effect of exposure (p<0.001). Urine iAs and metabolites showed a significant interaction effect between exposure and birth weight. Moderately exposed women with low compared to normal birth weight outcome had greater metabolite excretion (p<0.03); 67% with low compared to 10% with normal birth weight outcome presented urine iAs >9 μg/L (p=0.019). Metabolic partitioning of iAs toward excretion may impair fetal growth. Prospective studies on iAs excretion before and during pregnancy may provide a biomarker for poor fetal growth risk.
Authors:
Elyssa R Gelmann; Eugen Gurzau; Anca Gurzau; Walter Goessler; Julie Kunrath; Catherine W Yeckel; Kathleen M McCarty
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Publication Detail:
Type:  Journal Article     Date:  2013-10-19
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  36     ISSN:  1872-7077     ISO Abbreviation:  Environ. Toxicol. Pharmacol.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-26     Completed Date:  2014-07-15     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1266-75     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Arsenicals / analysis,  metabolism*,  urine
Birth Weight / drug effects*
Drinking Water / analysis
Female
Humans
Infant
Methylation
Nails / chemistry
Pilot Projects
Pregnancy
Romania / epidemiology
Socioeconomic Factors
Spectrophotometry, Atomic
Water Pollutants, Chemical / adverse effects
Young Adult
Grant Support
ID/Acronym/Agency:
L30 CA124219/CA/NCI NIH HHS; L30 ES019436/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Arsenicals; 0/Drinking Water; 0/Water Pollutants, Chemical
Comments/Corrections

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