Document Detail

A pilot study on the effects of exercise in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  14635294     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A pilot study was designed to assess the efficacy and safety of different exercise therapies on patient-reported fatigue and functional status. METHODS: Ten patients with systemic lupus erythematosus (SLE) were randomly placed in either an aerobic exercise group (group 1: n = 5) or a range of motion/muscle strengthening (ROM/MS) exercise group (group 2: n = 5). Outcome measures assessed at baseline and the end of the study were fatigue, functional status, disease activity, cardiovascular fitness, isometric strength, bone mineral density (BMD) of the lumbar spine and femoral neck, and parathyroid hormone and osteocalcin as representative bone biochemical markers for bone resorption and bone formation, respectively. RESULTS: Both aerobic and ROM/MS types of exercise were safe and did not worsen SLE disease activity. Patients in both exercise groups showed some improvement in fatigue, functional status, cardiovascular fitness, and muscle strength. Both groups showed increased bone turnover, but BMD was unchanged. Eighty percent of the patients met the compliance standard for the study. CONCLUSIONS: This pilot study shows the feasibility of exercise for SLE patients. The potential value of this approach shows promise in the routine management of these patients.
R Ramsey-Goldman; E M Schilling; D Dunlop; C Langman; P Greenland; R J Thomas; R W Chang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis care and research : the official journal of the Arthritis Health Professions Association     Volume:  13     ISSN:  0893-7524     ISO Abbreviation:  Arthritis Care Res     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2003-11-25     Completed Date:  2003-12-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8809082     Medline TA:  Arthritis Care Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  262-9     Citation Subset:  N    
Department of Medicine, Division of Arthritis, Northwestern University Medical School, Chicago, Illinois, USA.
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MeSH Terms
Activities of Daily Living
Bone Density
Exercise Therapy / methods*
Fatigue / etiology
Feasibility Studies
Lupus Erythematosus, Systemic / complications,  physiopathology,  rehabilitation*
Middle Aged
Physical Fitness
Pilot Projects
Range of Motion, Articular
Severity of Illness Index
Treatment Outcome
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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