| A pilot study for the effects of donepezil therapy on cerebral and optic nerve head blood flow, visual field defect in normal-tension glaucoma. | |
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MedLine Citation:
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PMID: 20415624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the effect of donepezil hydrochloride, an agent for the treatment of Alzheimer's disease (AD), on the cerebral and optic nerve head (ONH) blood flow, visual field defect in normal-tension glaucoma (NTG) patients with decreased cerebral blood flow (CBF) that demonstrates an AD-like perfusion pattern. METHODS: The subjects were 5 NTG patients who exhibited AD-like decreased CBF upon (123)I-iodoamphetamine single photon emission computed tomography ((123)I-IMP SPECT). Donepezil hydrochloride (5 mg/day) was prescribed for each patient during a period of 12 months. Intraocular pressure (IOP), mean deviation (MD) of the Humphrey visual field, ONH blood flow determined by a laser speckle flowgraphy, and regional CBF (rCBF) determined by (123)I-IMP SPECT were measured before and every 6 months during the treatment. RESULTS: MD, ONH blood flow, and rCBF were improved significantly after 6 months of the treatment, although IOP did not change significantly. No deterioration of NTG morbidity was found in any of the measured parameters after 12 months of the treatment. CONCLUSIONS: Oral administration of donepezil hydrochloride in NTG patients might prevent deterioration of visual field defect, ONH blood flow, and rCBF in the temporal, parietal, and posterior lobes. This pilot study suggested the possibility that donepezil hydrochloride might ameliorate glaucomatous optic neuropathy in NTG. |
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Authors:
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Yukiko Yoshida; Tetsuya Sugiyama; Keita Utsunomiya; Yasuharu Ogura; Tsunehiko Ikeda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Volume: 26 ISSN: 1557-7732 ISO Abbreviation: J Ocul Pharmacol Ther Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9511091 Medline TA: J Ocul Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Ujigawa Hospital, vji, Kyoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Blood Flow Velocity / drug effects Brain / blood supply* Cerebrovascular Circulation / drug effects Cholinesterase Inhibitors / therapeutic use* Female Humans Indans / therapeutic use* Intraocular Pressure / drug effects Iofetamine / diagnostic use Laser-Doppler Flowmetry Low Tension Glaucoma / drug therapy*, physiopathology* Male Optic Disk / blood supply* Pilot Projects Piperidines / therapeutic use* Radiopharmaceuticals / diagnostic use Regional Blood Flow / drug effects Tomography, Emission-Computed, Single-Photon Vision Disorders / prevention & control* Visual Fields / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Indans; 0/Piperidines; 0/Radiopharmaceuticals; 120011-70-3/donepezil; 95896-48-3/Iofetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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