Document Detail


A pilot study on chemospecific duodenal visceral sensitivity in inflammatory bowel disease in remission.
MedLine Citation:
PMID:  16837799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with inflammatory bowel disease (IBD) in remission frequently experience symptoms resembling irritable bowel syndrome (IBS). In IBS altered motility and visceral sensitivity are found throughout the whole gastrointestinal tract. We aimed to study chemospecific antroduodenal sensitivity in IBD patients. METHODS: Antroduodenal manometry was performed in 10 IBD patients in remission and 13 controls. Small volumes of nutrients and acid were administered intraduodenally. Motility variables and sensation scores were compared before and after each infusion. RESULTS: Acid and lipid infusion decreased the number of antral pressure waves in both groups (p < 0.05). After acid infusion the number of duodenal pressure waves in the sideholes just distal to the infusion port increased in IBD patients compared to the controls (p < 0.05). Lipid infusion increased the number of duodenal propagated pressure waves in both groups, but in controls they were also increased over longer distances (p < 0.005). None of the infusions significantly affected the sensation scores. CONCLUSION: Subtle alterations in chemospecific responses to lipids and acid in IBD patients in remission were observed, affecting duodenal motor activity but not duodenal perception. These changes are indicative of changes at the chemoreceptor level in the duodenal wall in this patient group.
Authors:
Itta M Minderhoud; André J Smout; Bas Oldenburg; Melvin Samsom
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Publication Detail:
Type:  Journal Article     Date:  2006-07-11
Journal Detail:
Title:  Digestion     Volume:  73     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-12-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  151-9     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, University Medical Centre Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Case-Control Studies
Chemoreceptor Cells / drug effects,  physiology*
Duodenum / drug effects,  physiopathology*
Female
Gastrointestinal Motility*
Humans
Hydrochloric Acid / pharmacology
Inflammatory Bowel Diseases / physiopathology*
Irritable Bowel Syndrome / physiopathology
Lipids / pharmacology
Male
Manometry
Middle Aged
Pilot Projects
Chemical
Reg. No./Substance:
0/Lipids; 7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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