Document Detail


A pilot study of carboplatin augmentation therapy for patients with poor risk acute non-lymphocytic leukemia.
MedLine Citation:
PMID:  1545569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eleven patients with acute non-lymphocytic leukemia and persistent leukemia on a bone marrow done 6 days after the start of standard induction chemotherapy with daunorubicin and cytosine arabinoside were given augmentation chemotherapy with carboplatin as a continuous intravenous infusion over 3 days. Nine of the 11 patients (82%) entered complete remission. The hematologic and non-hematologic toxicities encountered by these patients were similar to those seen after conventional therapy alone with the exception of peripheral neuropathy in one patient. Of the two induction failures, one patient died of treatment-related toxicity and one patient had resistant leukemia.
Authors:
A M Benger; G P Browman; I R Walker; R M Meyer; W E Wilson; J A McBride
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Leukemia research     Volume:  16     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  1992  
Date Detail:
Created Date:  1992-04-15     Completed Date:  1992-04-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
Affiliation:
Hamilton Civic Hospital, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bone Marrow / pathology
Carboplatin / administration & dosage*,  adverse effects
Humans
Kidney Diseases / chemically induced
Leukemia, Myeloid, Acute / drug therapy*,  pathology
Middle Aged
Chemical
Reg. No./Substance:
41575-94-4/Carboplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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