Document Detail

A pilot study associating urinary concentrations of phthalate metabolites and semen quality.
MedLine Citation:
PMID:  18570050     Owner:  NLM     Status:  MEDLINE    
Phthalates are ubiquitous industrial chemicals that are reported to adversely affect human reproductive outcomes. Divergent effects on semen quality have been reported in a limited number of studies. To assess the possible contribution of regional differences in phthalate exposure to these results, we wished to determine if ambient phthalate exposure of men from the Great Lakes region was associated with human sperm parameters. Male partners (N=45) of subfertile couples presenting to a Michigan infertility clinic were recruited. Urinary concentrations of several phthalate metabolites were measured in these men. Semen parameters, measured according to the World Health Organization [WHO 1999] protocols, were divided into those at or above WHO cutoffs for motility (50% motile), concentration (20 million/mL) and morphology (4% normal) and those below. Phthalate metabolite concentrations were divided into those concentrations above the median and those at or below the median. Specific gravity was used as a covariate in the regression models to adjust for urine dilution. Low sperm concentration was significantly associated with above median concentrations of monoethyl phthalate (MEP) (OR=6.5, 95% CI: 1.0-43.6) and low morphology with above median concentrations of mono-3-carboxypropyl phthalate (OR=7.6, 95% CI: 1.7-33.3). Increased odds for low concentration and above median concentrations of metabolites of di(2-ethylhexyl) phthalate (DEHP) (OR=5.4, 95% CI: 0.9-30.8) and low morphology and above median concentrations of MEP (OR=3.4, 95% CI: 0.9-13.8) were also found. A significant trend was observed for tertiles of MEP and low sperm concentration (p=0.05). Results suggest that ambient phthalate metabolite concentrations may adversely affect human semen quality.
Julia J Wirth; Mary G Rossano; Rachel Potter; Elizabeth Puscheck; Douglas C Daly; Nigel Paneth; Stephen A Krawetz; Bridget M Protas; Michael P Diamond
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Systems biology in reproductive medicine     Volume:  54     ISSN:  1939-6368     ISO Abbreviation:  Syst Biol Reprod Med     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-09-12     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101464963     Medline TA:  Syst Biol Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-54     Citation Subset:  IM    
Department of Epidemiology, Michigan State University, East Lansing, Michigan, USA.
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MeSH Terms
Diethylhexyl Phthalate / adverse effects
Great Lakes Region
Infertility, Male / chemically induced*,  pathology
Middle Aged
Odds Ratio
Phthalic Acids / adverse effects*,  urine
Pilot Projects
Risk Assessment
Semen / drug effects*
Sperm Count
Sperm Motility / drug effects
Spermatozoa / drug effects*,  pathology
Water Pollutants, Chemical / adverse effects*,  urine
Grant Support
Reg. No./Substance:
0/Phthalic Acids; 0/Water Pollutants, Chemical; 0/monomethyl phthalate; 117-81-7/Diethylhexyl Phthalate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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