| A pilot study of 2',3'-dideoxyinosine for the treatment of chronic hepatitis B. | |
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MedLine Citation:
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PMID: 1398494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nucleoside analog 2',3'-dideoxyinosine, currently being used to treat patients infected with the human immunodeficiency virus, has been shown to inhibit viral replication in certain cell culture systems of hepatitis B virus and the duck model of chronic hepatitis B infection. We studied the effect of dideoxyinosine on viral replication in patients with chronic hepatitis B. In the initial dose-finding phase, patients received sequential 2-wk courses of dideoxyinosine in escalating doses of 3, 6 and 9 mg/kg/day. In the second, long-term treatment phase, patients received dideoxyinosine at a dose of 9 mg/kg/day for 12 wk. Dideoxyinosine was given orally in three divided doses. The effects of dideoxyinosine on hepatitis B were assessed by serial measurements of ALT, hepatitis B virus DNA and DNA polymerase activity in serum. Six patients completed the dose-finding phase, and five patients continued into the long-term treatment phase. No significant differences were seen in serum aminotransferases, hepatitis B virus DNA levels or DNA polymerase activity at any time during treatment when compared with pretreatment levels. All patients remained positive for HBeAg during treatment and during 6 mo of follow-up. Thus at the doses tested, dideoxyinosine had no appreciable effect on viral replication in patients with chronic hepatitis B. |
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Authors:
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M W Fried; J C Korenman; A M Di Bisceglie; Y Park; J G Waggoner; H Mitsuya; N R Hartman; R Yarchoan; S Broder; J H Hoofnagle |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 16 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 861-4 Citation Subset: IM; X |
Affiliation:
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Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chronic Disease DNA, Viral / blood DNA-Directed DNA Polymerase / blood Didanosine / therapeutic use* Hepatitis B / blood, drug therapy*, genetics Hepatitis B virus / genetics Humans Male Pilot Projects |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 69655-05-6/Didanosine; EC 2.7.7.7/DNA-Directed DNA Polymerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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