Document Detail


A pilot study of 2',3'-dideoxyinosine for the treatment of chronic hepatitis B.
MedLine Citation:
PMID:  1398494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nucleoside analog 2',3'-dideoxyinosine, currently being used to treat patients infected with the human immunodeficiency virus, has been shown to inhibit viral replication in certain cell culture systems of hepatitis B virus and the duck model of chronic hepatitis B infection. We studied the effect of dideoxyinosine on viral replication in patients with chronic hepatitis B. In the initial dose-finding phase, patients received sequential 2-wk courses of dideoxyinosine in escalating doses of 3, 6 and 9 mg/kg/day. In the second, long-term treatment phase, patients received dideoxyinosine at a dose of 9 mg/kg/day for 12 wk. Dideoxyinosine was given orally in three divided doses. The effects of dideoxyinosine on hepatitis B were assessed by serial measurements of ALT, hepatitis B virus DNA and DNA polymerase activity in serum. Six patients completed the dose-finding phase, and five patients continued into the long-term treatment phase. No significant differences were seen in serum aminotransferases, hepatitis B virus DNA levels or DNA polymerase activity at any time during treatment when compared with pretreatment levels. All patients remained positive for HBeAg during treatment and during 6 mo of follow-up. Thus at the doses tested, dideoxyinosine had no appreciable effect on viral replication in patients with chronic hepatitis B.
Authors:
M W Fried; J C Korenman; A M Di Bisceglie; Y Park; J G Waggoner; H Mitsuya; N R Hartman; R Yarchoan; S Broder; J H Hoofnagle
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  16     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-19     Completed Date:  1992-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  861-4     Citation Subset:  IM; X    
Affiliation:
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chronic Disease
DNA, Viral / blood
DNA-Directed DNA Polymerase / blood
Didanosine / therapeutic use*
Hepatitis B / blood,  drug therapy*,  genetics
Hepatitis B virus / genetics
Humans
Male
Pilot Projects
Chemical
Reg. No./Substance:
0/DNA, Viral; 69655-05-6/Didanosine; EC 2.7.7.7/DNA-Directed DNA Polymerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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