| A pilot investigation to subjectively measure treatment effect and side-effect profile of non-ablative skin remodeling using a 532 nm, 2 ms pulse-duration laser. | |
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MedLine Citation:
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PMID: 12006190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Carbon dioxide laser skin resurfacing has become a standard treatment for wrinkles and sun-damaged skin. This ablative treatment, however, is associated with undesirable complications and long recovery times. A growing body of evidence suggests that dermal inflammation and subsequent collagen formation can be stimulated without removal of the epidermis, raising the possibility of effective non-ablative skin remodeling for mild to moderately photodamaged skin. MATERIALS AND METHODS: This preliminary study was performed to evaluate the safety and subject satisfaction of non-ablative skin remodeling using a 532 nm, 2 ms pulse-duration, frequency-doubled Nd:YAG laser. Subjects with mild-to-deep lip wrinkles and mild-moderate acne scarring were treated one half of their lip (wrinkles) or cheek (acne scarring), leaving the other side as an untreated control. Subjects were treated at 3-6 week intervals for an average of three treatments. Subjective assessment of improvement was estimated by subject self-evaluation of the percentage improvement over baseline, and a blinded observer attempted to identify the treated side on physical examination. RESULTS: Subjective assessment revealed an average improvement of 51.4% and 53.6% for upper lip wrinkles and facial acne scarring, respectively. Side effects were limited to transient erythema that resolved over 0.25-2 hours following treatment. CONCLUSIONS: These results demonstrate that non-ablative treatment with the 532 nm, 2 ms pulse-duration Nd:YAG laser results in subjective improvement of rhytides and acne scarring, with a high safety profile. |
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Authors:
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E F Bernstein; M Ferreira; D Anderson |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Volume: 3 ISSN: 1476-4172 ISO Abbreviation: J Cosmet Laser Ther Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2002-05-13 Completed Date: 2002-05-29 Revised Date: 2010-03-23 |
Medline Journal Info:
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Nlm Unique ID: 101136419 Medline TA: J Cosmet Laser Ther Country: England |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Affiliation:
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Laser Surgery and Cosmetic Dermatology Centers, Marlton, NJ, USA. dermguy@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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complications Adult Cicatrix / etiology, surgery Face / surgery Female Humans Laser Therapy* / adverse effects, instrumentation, methods Middle Aged Patient Satisfaction Pilot Projects Reconstructive Surgical Procedures / methods* Skin / surgery* Skin Aging Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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