Document Detail

A pilot investigation to subjectively measure treatment effect and side-effect profile of non-ablative skin remodeling using a 532 nm, 2 ms pulse-duration laser.
MedLine Citation:
PMID:  12006190     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Carbon dioxide laser skin resurfacing has become a standard treatment for wrinkles and sun-damaged skin. This ablative treatment, however, is associated with undesirable complications and long recovery times. A growing body of evidence suggests that dermal inflammation and subsequent collagen formation can be stimulated without removal of the epidermis, raising the possibility of effective non-ablative skin remodeling for mild to moderately photodamaged skin. MATERIALS AND METHODS: This preliminary study was performed to evaluate the safety and subject satisfaction of non-ablative skin remodeling using a 532 nm, 2 ms pulse-duration, frequency-doubled Nd:YAG laser. Subjects with mild-to-deep lip wrinkles and mild-moderate acne scarring were treated one half of their lip (wrinkles) or cheek (acne scarring), leaving the other side as an untreated control. Subjects were treated at 3-6 week intervals for an average of three treatments. Subjective assessment of improvement was estimated by subject self-evaluation of the percentage improvement over baseline, and a blinded observer attempted to identify the treated side on physical examination. RESULTS: Subjective assessment revealed an average improvement of 51.4% and 53.6% for upper lip wrinkles and facial acne scarring, respectively. Side effects were limited to transient erythema that resolved over 0.25-2 hours following treatment. CONCLUSIONS: These results demonstrate that non-ablative treatment with the 532 nm, 2 ms pulse-duration Nd:YAG laser results in subjective improvement of rhytides and acne scarring, with a high safety profile.
E F Bernstein; M Ferreira; D Anderson
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology     Volume:  3     ISSN:  1476-4172     ISO Abbreviation:  J Cosmet Laser Ther     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2002-05-13     Completed Date:  2002-05-29     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  101136419     Medline TA:  J Cosmet Laser Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-41     Citation Subset:  IM    
Laser Surgery and Cosmetic Dermatology Centers, Marlton, NJ, USA.
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MeSH Terms
Acne Vulgaris / complications
Cicatrix / etiology,  surgery
Face / surgery
Laser Therapy* / adverse effects,  instrumentation,  methods
Middle Aged
Patient Satisfaction
Pilot Projects
Reconstructive Surgical Procedures / methods*
Skin / surgery*
Skin Aging
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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