Document Detail


The pigmented life of a redhead.
MedLine Citation:
PMID:  15016311     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As a redhead I have had a personal interest in red hair, freckles and sunburns since childhood. An observation of a formaldehyde-induced fluorescence in human epidermal melanocytes initiated my scientific interest in these cells. Prota and Nicolaus demonstrated that oxidation products of cysteinyldopas are the main components of pheomelanin. Our identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. All melanocytes with functioning tyrosinase produce cysteinyldopas and the levels of 5-S-cysteinyldopa in serum and urine are related to the size and pigment forming activity of the melanocyte population. The determination of 5-S-cysteinyldopa in serum or urine is a sensitive diagnostic method in the detection of melanoma metastasis. Some non-specific formation of cysteinyldopa is present in the body, as demonstrated by 5-S-cysteinyldopa in individuals with tyrosinase-negative albinism.
Authors:
Hans Rorsman
Publication Detail:
Type:  Biography; Historical Article; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society     Volume:  17     ISSN:  0893-5785     ISO Abbreviation:  Pigment Cell Res.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-12     Completed Date:  2004-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800247     Medline TA:  Pigment Cell Res     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  191-202     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of Lund, Lund, Sweden. hans.rorsman@derm.lu.se
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MeSH Terms
Descriptor/Qualifier:
Albinism / metabolism
Biochemistry / history
Hair / metabolism*
History, 20th Century
Humans
Melanocytes / metabolism
Personal Name Subject
Personal Name Subject:
Hans Rorsman

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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