Document Detail


A phytotherapeutic approach to Nigerian anti-HIV and immunomodulatory drug discovery.
MedLine Citation:
PMID:  18050777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effective therapies for management of HIV infection are top priority due to the high rate of morbidity and mortality of the disease, globally and this has assumed devastating dimension in the African continent. In Nigeria, many patients use herbal remedies for the management of HIV/AIDS, without sufficient scientific proof that they possess anti-HIV activity. In this report, the role of the tropical rainforest plants, identified through ethnomedical approach, as a source of antiviral and immunomodulating agents is highlighted. Some plant derived antiviral and immunomodulatory agents are briefly discussed. An outline of in vitro antiviral and immunomodulatory assays that can be adapted to the Nigerian environment is given. The urgent need to identify and evaluate the medicinal plants in the Nigerian biodiversity reputedly used for management of viral infections is also emphasized.
Authors:
E O Ajaiyeoba; O O Ogbole
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  African journal of medicine and medical sciences     Volume:  35 Suppl     ISSN:  0309-3913     ISO Abbreviation:  Afr J Med Med Sci     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-12-03     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801013     Medline TA:  Afr J Med Med Sci     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
Affiliation:
Department of Pharmnacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.
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MeSH Terms
Descriptor/Qualifier:
HIV Infections / drug therapy*,  epidemiology,  immunology
Humans
Immunologic Factors / therapeutic use*
Nigeria / epidemiology
Phytotherapy / methods*
Plant Preparations / therapeutic use*
Prevalence
Treatment Outcome
Chemical
Reg. No./Substance:
0/Immunologic Factors; 0/Plant Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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