Document Detail


The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors.
MedLine Citation:
PMID:  12429027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some plant compounds or herb mixtures are popular alternatives to conventional therapies and contain organic compounds that bind to some nuclear receptors, such as the estrogen receptor (ER), to exert various biological effects. We studied the effect of various herbal extracts on ERalpha and ERbeta isoforms. One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbeta. The phytochemical lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ERalpha and ERbeta. 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of lindleyin. Lindleyin binds to ERalpha in vitro, as demonstrated using a fluorescent polarization assay. The in vivo effect of rhubarb extract was studied using a vitellogenin assay system in the freshwater fish, Japanese medaka (Oryzias latipes). There were marked increases in serum vitellogenin levels in male medaka exposed to rhubarb extract. We conclude that lindleyin, a component of some herbal medicines, is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
Authors:
T Usui; Y Ikeda; T Tagami; K Matsuda; K Moriyama; K Yamada; H Kuzuya; S Kohno; A Shimatsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  175     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2003-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  289-96     Citation Subset:  IM    
Affiliation:
Clinical Research Institute, Center for Endocrine and Metabolic Disease, Kyoto National Hospital, Kyoto, Japan. tusui@kyotolan.hosp.go.jp
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Estrogen Receptor alpha
Estrogen Receptor beta
Fluorescence Polarization / methods
Glucosides / metabolism*
Humans
Plant Extracts / metabolism
Receptors, Estrogen / metabolism*
Rheum / metabolism*
Transfection / methods
Vitellogenins / metabolism
Chemical
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Estrogen Receptor beta; 0/Glucosides; 0/Plant Extracts; 0/Receptors, Estrogen; 0/Vitellogenins; 59282-56-3/lindleyin

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