| A physiologically representative in vitro model of the coronary circulation. | |
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MedLine Citation:
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PMID: 15382829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With the development of clinical diagnostic techniques to investigate the coronary circulation in conscious humans, the in vitro validation of such newly developed techniques is of major importance. The aim of this study was to develop an in vitro model that is able to mimic the coronary circulation in such a way that coronary pressure and flow signals under baseline as well as hyperaemic conditions are approximated as realistically as possible and are in accordance with recently gained insights into such signals in conscious man. In the present in vitro model the heart, the systemic and coronary circulation are modelled on the basis of the elements of a lumped parameter mathematical model only consisting of elements that can be represented by segments in an experimental set-up. A collapsible tube, collapsed by the ventricular pressure, represents the variable resistance and volume behaviour of the endocardial part of the myocardium. The pressure and flow signals obtained are similar to physiological human coronary pressure and flow, both for baseline and hyperaemic conditions. The model allows for in vitro evaluation of clinical diagnostic techniques. |
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Authors:
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Maartje C F Geven; Vincent N Bohté; Wilbert H Aarnoudse; Petra M J van den Berg; Marcel C M Rutten; Nico H J Pijls; Frans N van de Vosse |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiological measurement Volume: 25 ISSN: 0967-3334 ISO Abbreviation: Physiol Meas Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-22 Completed Date: 2004-11-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306921 Medline TA: Physiol Meas Country: England |
Other Details:
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Languages: eng Pagination: 891-904 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands. M.C.F.Geven@tue.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure* Coronary Vessels / physiology* Heart / physiology* Humans Models, Biological* Regional Blood Flow |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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