| A physiologically based mathematical model of dermal absorption in man. | |
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MedLine Citation:
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PMID: 8198830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the model parallels the multi-layer structure of the skin, with separate surface, stratum corneum and viable tissue layers. It simulates the effects of partitioning and diffusive transport between the sub-layers, and metabolism in the viable epidermis. In addition the model describes removal processes on the surface of the skin, including the effects of washing and desquamation, and rubbing off onto clothing. This model is applied to data on the penetration of the herbicide fluazifop-butyl through human skin in vivo and in vitro. Part of this dataset is used to estimate unknown model parameter values and the remainder is used to provide a partial validation of the model. Only a small fraction of the applied dose was absorbed through the skin; most of it was removed by washing or onto clothing. The model provides a quantitative description of these loss processes on the skin surface. |
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Authors:
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T R Auton; D R Westhead; B H Woollen; R C Scott; M F Wilks |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Human & experimental toxicology Volume: 13 ISSN: 0960-3271 ISO Abbreviation: Hum Exp Toxicol Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-07-05 Completed Date: 1994-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 51-60 Citation Subset: IM |
Affiliation:
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Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Epidermis / drug effects Humans Models, Theoretical* Pyridines / administration & dosage, pharmacokinetics Skin Absorption / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Pyridines; 69806-50-4/fluazifop-butyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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