| The physiological significance of coronary aneurysms in Kawasaki disease. | |
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MedLine Citation:
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PMID: 22157479 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aims: A coronary aneurysm is one of the most frequent complications of Kawasaki disease, and yet there is little information concerning the haemodynamic abnormality influenced by the existence of a coronary aneurysm. When blood flow passes through an aneurysm, the turbulence that then occurs means that part of the initial energy is lost, and that energy loss could cause a drop in pressure, such as when passing through a stenotic lesion. The aim of this study is to prove the hypothesis that a giant aneurysm haemodynamically acts in a manner similar to that of stenosis. Methods and results: The study population consisted of 47 patients with a simple coronary aneurysm after Kawasaki disease. Fractional flow reserve was measured in 32 coronary aneurysms. The fractional flow reserve in non-giant aneurysms was 0.95±0.03 and 0.90±0.03 in giant aneurysms (p=0.0004). Conclusions: The present data demonstrated that the coronary aneurysm could give rise to a small decline of pressure along the artery. Since no aneurysm demonstrated a fractional flow reserve under 0.75, a simple aneurysm would not cause coronary ischaemia by itself. However, it could trigger a coronary ischaemia in case of multiple coronary aneurysms and a coronary aneurysm with mild stenosis. |
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Authors:
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Tomoaki Murakami; Nobuhiro Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology Volume: 7 ISSN: 1969-6213 ISO Abbreviation: EuroIntervention Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101251040 Medline TA: EuroIntervention Country: France |
Other Details:
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Languages: eng Pagination: 944-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Chiba Cardiovascular, Ichihara Center, Chiba, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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