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The physiological significance of coronary aneurysms in Kawasaki disease.
MedLine Citation:
PMID:  22157479     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aims: A coronary aneurysm is one of the most frequent complications of Kawasaki disease, and yet there is little information concerning the haemodynamic abnormality influenced by the existence of a coronary aneurysm. When blood flow passes through an aneurysm, the turbulence that then occurs means that part of the initial energy is lost, and that energy loss could cause a drop in pressure, such as when passing through a stenotic lesion. The aim of this study is to prove the hypothesis that a giant aneurysm haemodynamically acts in a manner similar to that of stenosis. Methods and results: The study population consisted of 47 patients with a simple coronary aneurysm after Kawasaki disease. Fractional flow reserve was measured in 32 coronary aneurysms. The fractional flow reserve in non-giant aneurysms was 0.95±0.03 and 0.90±0.03 in giant aneurysms (p=0.0004). Conclusions: The present data demonstrated that the coronary aneurysm could give rise to a small decline of pressure along the artery. Since no aneurysm demonstrated a fractional flow reserve under 0.75, a simple aneurysm would not cause coronary ischaemia by itself. However, it could trigger a coronary ischaemia in case of multiple coronary aneurysms and a coronary aneurysm with mild stenosis.
Authors:
Tomoaki Murakami; Nobuhiro Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  7     ISSN:  1969-6213     ISO Abbreviation:  EuroIntervention     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  944-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Chiba Cardiovascular, Ichihara Center, Chiba, Japan.
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