Document Detail

The physiological role of estriol during human fetal development is to act as antioxidant at lipophilic milieus of the central nervous system.
MedLine Citation:
PMID:  11133265     Owner:  NLM     Status:  MEDLINE    
Estriol is the most abundant estrogen during human pregnancy, it has a low estrogenic effect and its physiological role is not known. Recently it has been shown that estrogens have antioxidant and free-radical scavenging activity; in free form estrogens are lipophilic, here it is proposed that the role of estriol is to act as antioxidant at level of the developing fetal central nervous system, whose tissues are substantially lipid in nature.
M A Reyes-Romero
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical hypotheses     Volume:  56     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  107-9     Citation Subset:  IM    
Food and Nutrition Research Center, Faculty of Medicine, Universidad Juárez del Estado de Durango, Durango, Dgo. Mexico.
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MeSH Terms
Antioxidants / metabolism*
Central Nervous System / embryology*,  metabolism
Embryonic and Fetal Development / physiology*
Estriol / physiology*
Lipid Metabolism*
Reg. No./Substance:
0/Antioxidants; 50-27-1/Estriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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