| The physiological role of the creatine kinase system: evolution of views. | |
| | |
MedLine Citation:
|
PMID: 11255118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The development of ideas concerning the buffer and transport functions of the creatine kinase system is described. The concept of ATP compartmentation at sites of its production and utilization is critically analyzed. Kinetic, thermodynamic, and structural data used as a basis for a hypothesis on the structural and functional coupling of mitochondrial creatine kinase and adenine nucleotide translocase are comprehensively analyzed, and experimental evidence inconsistent with this hypothesis is presented. It seems that the mitochondrial creatine kinase may serve to equilibrate ADP concentration in the intermembrane space with fluctuating ADP concentrations in the cytoplasm. It is suggested that creatine kinase molecules bound to other intracellular structures (e.g., to myofibrils) may equilibrate local ADP concentrations with those present in the cytoplasm. |
| | |
Authors:
|
T Y Lipskaya |
Related Documents
:
|
2393658 - Contact site between inner and outer mitochondrial membrane: a dynamic microcompartment... 17696488 - Active site modifications of the brain isoform of creatine kinase by 4-hydroxy-2-nonena... 11001578 - Reversible downregulation of telomerase activity by hyperthermia in osteosarcoma cells. 856488 - Stability of commonly used thiols and of human creatine kinase isoenzymes during storag... 15698508 - Mapk activation via 5-hydroxytryptamine 1a receptor is involved in the neuroprotective ... 21899548 - Azithromycin suppresses proliferation, interleukin production and mitogen-activated pro... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Biochemistry. Biokhimii͡a Volume: 66 ISSN: 0006-2979 ISO Abbreviation: Biochemistry Mosc. Publication Date: 2001 Feb |
Date Detail:
|
Created Date: 2001-03-20 Completed Date: 2001-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0376536 Medline TA: Biochemistry (Mosc) Country: United States |
Other Details:
|
Languages: eng Pagination: 115-29 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia. litaglep@mtu-net.ru |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Diphosphate
/
metabolism Creatine Kinase / chemistry, metabolism, physiology* Kinetics Protein Conformation Protein Transport Thermodynamics |
| Chemical | |
Reg. No./Substance:
|
58-64-0/Adenosine Diphosphate; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biochemical and morphological changes in carp (Cyprinus carpio L.) liver following exposure to coppe...
Next Document: Matrix metalloproteinases of normal human tissues.