Document Detail

A physiological model of patient-reported breathlessness during daily activities in COPD.
MedLine Citation:
PMID:  20956127     Owner:  NLM     Status:  MEDLINE    
Breathlessness during daily activities has a significant impact on quality of life in chronic obstructive pulmonary disease. Herein, we present a physiological model of patient-reported breathlessness based on the relationship between ventilatory load, respiratory muscle capacity, neural respiratory drive and neuromechanical dissociation during daily activities. This model should facilitate an understanding of the mechanisms driving increased intensity of breathlessness during daily activities and the relief of breathlessness following medical or surgical interventions. The model should also provide a structure on which to base the development of patient-reported outcome instruments to measure the severity of breathlessness during daily activities in chronic obstructive pulmonary disease.
C J Jolley; J Moxham
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European respiratory review : an official journal of the European Respiratory Society     Volume:  18     ISSN:  1600-0617     ISO Abbreviation:  Eur Respir Rev     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-02-28     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9111391     Medline TA:  Eur Respir Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  66-79     Citation Subset:  IM    
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MeSH Terms
Activities of Daily Living*
Dyspnea / physiopathology*
Models, Biological
Posture / physiology
Pulmonary Disease, Chronic Obstructive / physiopathology*
Respiratory Mechanics
Grant Support
G0500411//Medical Research Council
Comment In:
Eur Respir Rev. 2009 Jun;18(112):54-7   [PMID:  20956125 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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