Document Detail

The physiological effects of short-term smoking cessation in claudicants.
MedLine Citation:
PMID:  19017673     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Smoking contributes to atherosclerosis and causes significant postoperative morbidity. New antismoking law forces short-term pre-operative abstinence. Demonstrable clinical benefit might motivate complete cessation. Our aim was to determine the effects of 24-hr smoking cessation on cardiorespiratory function and claudication distance. METHODS: Smoking claudicants were randomized to 24hr smoking or abstinence. Following these separate periods, cardiopulmonary exercise testing was performed. Pre- and post-exercise, serum lactate and ankle brachial pressure index (ABPI) were measured. During exercise, cardiorespiratory function, initial and absolute claudication (IC,AC) distances and visual analogue scores (VAS) of pain were recorded. RESULTS: 16 patients completed both tests. IC, AC and VAS were unchanged with abstinence (P = .43, .66, .96, .83). ABPI drop post-exercise was unchanged with abstinence (P = .08, .09). Cardiorespiratory function was not affected by smoking cessation. CONCLUSION: Cardiorespiratory function and claudication symptoms are unchanged following 24-hr smoking cessation. No deterioration in respiratory function is important when considering anaesthetic administration. However, lack of symptomatic improvement may discourage patients from abstaining. Further investigation should determine correlation between short-term abstinence and postoperative morbidity.
K J Dickinson; A J Cockbain; W MacDonald; M Shah; S Homer-Vanniasinkam
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-11-17
Journal Detail:
Title:  Angiology     Volume:  60     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:    2009 Apr-May
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
Leeds Vascular Institute, Leeds General Infirmary, Leeds, United Kingdom.
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MeSH Terms
Exercise Test
Follow-Up Studies
Hemodynamics / physiology*
Intermittent Claudication / physiopathology*,  therapy
Middle Aged
Respiratory Function Tests
Respiratory Physiological Phenomena
Smoking / adverse effects
Smoking Cessation / methods*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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