Document Detail


The physiological cost of gait (PCG): a new technique for evaluating nonsteroidal anti-inflammatory drugs in rheumatoid arthritis.
MedLine Citation:
PMID:  6347305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physiological cost of gait (PCG) provides a technique for reproducibly quantifying the physical disabilities occasioned by inflammatory joint disease. The preferred walking speed (PWS) and the physiological cost index (PCI) related to achieving that PWS are shown to be abnormal in rheumatoid arthritis (RA) and objective improvement can be demonstrated with naproxen and indomethacin, two commonly-used nonsteroidal anti-inflammatory drugs (NSAIDs). Twenty patients with active RA were studied by double-blind cross-over technique and 16 completed the two-month study. Reliable PCG data obtained in 13 patients showed statistically significant improvement in PWS and PCI with NSAID therapy. Improvement was not correlated with conventional clinical measures of joint inflammation such as pain score, articular index, haemoglobin or ESR but the trends were similar. PCG may offer a reproducible, objective method of quantifying disability and response to treatment.
Authors:
M M Steven; H A Capell; R D Sturrock; J MacGregor
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of rheumatology     Volume:  22     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / drug therapy*,  physiopathology
Biomechanics
Clinical Trials as Topic
Delayed-Action Preparations
Double-Blind Method
Female
Gait*
Heart Rate*
Humans
Indomethacin / therapeutic use*
Male
Methods
Middle Aged
Naproxen / therapeutic use*
Random Allocation
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 22204-53-1/Naproxen; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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