| The physiological and anatomical demonstration of functionally selective parasympathetic ganglia located in discrete fat pads on the feline myocardium. | |
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MedLine Citation:
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PMID: 7769158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments utilizing surgical parasympathectomy of discrete fat pad ganglia on the surface of the heart have suggested that there are two anatomically segregated and physiologically independent parasympathetic intracardiac ganglia which are capable of selective control of sino-atrial (SA) rate and atrio-ventricular (AV) conduction. Some pharmacological data, however, are inconsistent with these conclusions. We have examined the cardiodynamic effects of discrete injections of a ganglionic blocking drug into two fat pads on the surface of the cat heart. These fat pads were shown to contain ganglion cells histologically. It was observed that vagal effects upon cardiac rate are selectively mediated by neurons located in ganglia overlying the right pulmonary veins at the junction of the right atrium and superior vena cava. On the other hand, vagal effects upon AV conduction were selectively mediated by neurons located in a fat pad at the junction of the inferior vena cava and the inferior left atrium. These pharmacological data support the concept that specific intracardiac ganglia are capable of selective control of SA rate and AV conduction. |
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Authors:
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P J Gatti; T A Johnson; P Phan; I K Jordan; W Coleman; V J Massari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the autonomic nervous system Volume: 51 ISSN: 0165-1838 ISO Abbreviation: J. Auton. Nerv. Syst. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-06-30 Completed Date: 1995-06-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8003419 Medline TA: J Auton Nerv Syst Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 255-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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innervation* Animals Cats Ganglia, Parasympathetic / anatomy & histology*, physiology* Heart / innervation* Heart Rate Myocardium / cytology Sinoatrial Node / innervation Trimethaphan / administration & dosage Vagus Nerve / physiology |
| Grant Support | |
ID/Acronym/Agency:
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NHLBI-44922/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7187-66-8/Trimethaphan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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