Document Detail

The physiologic effects of isoflurane anesthesia in neonatal mice.
MedLine Citation:
PMID:  16368807     Owner:  NLM     Status:  MEDLINE    
In neonatal rodents, isoflurane has been shown to confer neurological protection during hypoxia-ischemia and to precipitate neurodegeneration after prolonged exposure. Whether neuroprotection or neurotoxicity result from a direct effect of isoflurane on the brain or an indirect effect through hemodynamic or metabolic changes remains unknown. We recorded arterial blood pressure, heart rate, blood gases, and glucose in 10-day-old mice during 60 min of isoflurane anesthesia with spontaneous or mechanical ventilation, as well as during 60 min of hypoxia-ischemia with isoflurane anesthesia or without anesthesia. During isoflurane anesthesia, hypoglycemia and metabolic acidosis occurred with spontaneous and mechanical ventilation. During hypoxia-ischemia, isoflurane was fatal with spontaneous breathing but survivable with mechanical ventilation, with arterial blood pressure and heart rate being similar to that observed in unanesthetized animals. Minimum alveolar concentration (MAC) was 2.3% in 10-day-old mice. In summary, isoflurane anesthesia precipitated hypoglycemia, which may have contributed to the neurodegeneration observed in neonatal rodents. Use of 0.8 MAC isoflurane for evaluation of neuroprotection during hypoxia-ischemia requires mechanical ventilation and glucose supplementation in this model.
Andreas W Loepke; John C McCann; C Dean Kurth; John J McAuliffe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  102     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-21     Completed Date:  2006-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-80     Citation Subset:  AIM; IM    
Department of Anesthesia, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
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MeSH Terms
Anesthetics, Inhalation*
Animals, Newborn
Blood Pressure / drug effects*,  physiology
Heart Rate / drug effects*,  physiology
Mice, Inbred C57BL
Respiration / drug effects*
Time Factors
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane
Comment In:
Anesth Analg. 2006 Jan;102(1):72-4   [PMID:  16368806 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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