| The physiologic effects of isoflurane anesthesia in neonatal mice. | |
| | |
MedLine Citation:
|
PMID: 16368807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In neonatal rodents, isoflurane has been shown to confer neurological protection during hypoxia-ischemia and to precipitate neurodegeneration after prolonged exposure. Whether neuroprotection or neurotoxicity result from a direct effect of isoflurane on the brain or an indirect effect through hemodynamic or metabolic changes remains unknown. We recorded arterial blood pressure, heart rate, blood gases, and glucose in 10-day-old mice during 60 min of isoflurane anesthesia with spontaneous or mechanical ventilation, as well as during 60 min of hypoxia-ischemia with isoflurane anesthesia or without anesthesia. During isoflurane anesthesia, hypoglycemia and metabolic acidosis occurred with spontaneous and mechanical ventilation. During hypoxia-ischemia, isoflurane was fatal with spontaneous breathing but survivable with mechanical ventilation, with arterial blood pressure and heart rate being similar to that observed in unanesthetized animals. Minimum alveolar concentration (MAC) was 2.3% in 10-day-old mice. In summary, isoflurane anesthesia precipitated hypoglycemia, which may have contributed to the neurodegeneration observed in neonatal rodents. Use of 0.8 MAC isoflurane for evaluation of neuroprotection during hypoxia-ischemia requires mechanical ventilation and glucose supplementation in this model. |
| | |
Authors:
|
Andreas W Loepke; John C McCann; C Dean Kurth; John J McAuliffe |
Related Documents
:
|
17006727 - The influence of sevoflurane on the bispectral index, regional cerebral oxygen saturati... 8519717 - Wrapping of the legs reduces the decrease in blood pressure following spinal anesthesia... 1849587 - Comparison of xylazine with tiletamine-zolazepam (telazol) and xylazine-ketamine anesth... 8547547 - Isoflurane versus sodium nitroprusside for the control of proximal hypertension during ... 2979067 - Shivering following cardiac surgery: hemodynamic changes and reversal. 8424577 - Hypocapnia worsens arterial blood oxygenation and increases va/q heterogeneity in canin... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 102 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-21 Completed Date: 2006-01-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
|
Languages: eng Pagination: 75-80 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesia, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA. andreas.loepke@cchmc.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthetics, Inhalation* Animals Animals, Newborn Blood Pressure / drug effects*, physiology Female Heart Rate / drug effects*, physiology Isoflurane* Male Mice Mice, Inbred C57BL Respiration / drug effects* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane |
| Comments/Corrections | |
Comment In:
|
Anesth Analg. 2006 Jan;102(1):72-4
[PMID:
16368806
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The safety and efficacy of spinal anesthesia for surgery in infants: the Vermont Infant Spinal Regis...
Next Document: Predicting which child-parent pair will benefit from parental presence during induction of anesthesi...