Document Detail


A physical map around the WAGR complex on the short arm of chromosome 11.
MedLine Citation:
PMID:  2570029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A long-range restriction map of part of the short arm of chromosome 11 including the WAGR region has been constructed using pulsed-field gel electrophoresis and a number of infrequently cutting restriction enzymes. A total of 15.4 Mbp has been mapped in detail, extending from proximal 11p14 to the distal part of 11p12. The map localizes 35 different DNA probes and reveals at least nine areas with features characteristic of HTF islands, some of which may be candidates for the different loci underlying the phenotype of the WAGR syndrome. This map will furthermore allow screening of DNA from individuals with WAGR-related phenotypes and from Wilms tumors for associated chromosomal rearrangements.
Authors:
M Gessler; G A Bruns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  5     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-29     Completed Date:  1989-09-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-55     Citation Subset:  IM    
Affiliation:
Genetics Division, Children's Hospital, Boston, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Chromosome Deletion*
Chromosomes, Human, Pair 11*
DNA / genetics
DNA Probes
Electrophoresis, Agar Gel / methods
Genetic Markers
Humans
Linkage (Genetics)
Multigene Family
Phenotype
Polymorphism, Restriction Fragment Length
Restriction Mapping*
Syndrome
Grant Support
ID/Acronym/Agency:
GM 34988/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/DNA Probes; 0/Genetic Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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