Document Detail


Is physical exercise possible in patients with critical cytopenia undergoing intensive chemotherapy for acute leukaemia or aggressive lymphoma?
MedLine Citation:
PMID:  19629631     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients undergoing intensive chemotherapy for acute leukaemia or aggressive lymphoma not only suffer from the direct side effects of chemotherapy such as infections due to long-lasting immuno-suppression and aplasia, but also from marked fatigue and the inability to do normal physical activity. Furthermore, especially in patients with severe thrombocytopenia, anaemia and leukopenia, doctors recommend abstaining from physical exercise due to the risk of potential bleeding and tissue damage. The normally recommended cutoff level to perform exercise is 50,000 platelets per microliter or haemoglobin of 8 g/dl. This leads to a vicious cycle of losing physical strength and muscle with subsequent development of treatment-related cachexia and an increased treatment mortality. As number of publications focus on the importance of physical exercise in patients with solid tumours, increasing evidence is found that suggests positive effects on major clinical endpoints such as rate of infection, quality of life and even relapse rate and overall survival. With this work, we intended to address whether intense supervised ergometer training is feasible in patients with severe pancytopenia and whether it has any effect on patients undergoing high-dose chemotherapy. Furthermore, this study was initiated as the groundwork for a large phase III randomised trial.
Authors:
Thomas Elter; Martina Stipanov; Eva Heuser; Michael von Bergwelt-Baildon; Wilhelm Bloch; Michael Hallek; Freerk Baumann
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-07-24
Journal Detail:
Title:  International journal of hematology     Volume:  90     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Affiliation:
Department of Hematology and Oncology, University of Cologne, Cologne, Germany. thomas.elter@uk-koeln.de
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Anemia / etiology,  physiopathology
Antineoplastic Agents / therapeutic use*
Clinical Trials, Phase III as Topic
Combined Modality Therapy
Exercise Therapy*
Feasibility Studies
Female
Humans
Leukemia / complications,  drug therapy*
Lymphoma / complications,  drug therapy*
Male
Middle Aged
Physical Fitness
Pilot Projects
Quality of Life
Randomized Controlled Trials as Topic
Sports
Thrombocytopenia / etiology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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