Document Detail

The physical-chemical basis for sex-related differences in uptake of fatty acids by the liver.
MedLine Citation:
PMID:  2730886     Owner:  NLM     Status:  MEDLINE    
The uptake of fatty acids by the liver was shown previously to be a non-catalyzed process, and rates of uptake were correlated to the affinity of the plasma membranes of liver cells for fatty acids. The experiments in this paper were designed to test whether the known differences in uptake and metabolism of free fatty acids by the livers of male and female rats could be understood based on differences in the affinities of the corresponding plasma membranes for these substrates. The relative affinities for palmitate and oleate of 'male' plasma membranes were found to be lower versus 'female' membranes. Measurements of uptake of palmitate from albumin-palmitate complexes by 'male' and 'female' perfused livers showed higher uptake rates by the latter when correlated with the concentration of the complex. However, the rates of uptake were identical when the concentrations of the fatty acid in the plasma membranes of male and female liver cells were the same.
N Noy; T M Donnelly; R B Cooper; D Zakim
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1003     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-18     Completed Date:  1989-07-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Department of Medicine, Cornell University Medical College, New York, NY 10021.
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MeSH Terms
Albumins / metabolism
Cell Membrane / metabolism
Fatty Acids / metabolism*
Liver / metabolism*
Palmitates / pharmacokinetics
Protein Binding
Rats, Inbred Strains
Sex Characteristics*
Grant Support
Reg. No./Substance:
0/Albumins; 0/Fatty Acids; 0/Palmitates

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