Document Detail

Is physical activity beneficial for recovery in temporal lobe epilepsy? Evidences from animal studies.
MedLine Citation:
PMID:  19059282     Owner:  NLM     Status:  MEDLINE    
Exposure to different physical and cognitive stimulus have been shown to induce extensive neuronal plasticity in both undamaged and injured central nervous system, such as enhanced neurogenesis in the dentate gyrus of the hippocampus, up-regulation of neurotrophic factors and improved learning and memory. Neuronal plasticity also is found during certain neurodegenerative conditions, including the temporal lobe epilepsy (TLE). TLE is the most common form of partial epilepsy, characterized by atrophy of mesial temporal structures, mossy fiber sprouting, spontaneous recurrent seizures and cognitive deficits. In view of the fact that physical activity has been found to be beneficial for treating animal models of Parkinson's, Alzheimer's and Huntington's diseases, there is considerable interest in determining the efficacy of this strategy for preventing or treating chronic TLE. This review discusses the positive effects of program of physical exercise in experimental models of epilepsy. Thus, considerations of the potential application of physical exercise strategy for preventing or treating TLE are highlighted.
Ricardo Mario Arida; Fulvio Alexandre Scorza; Carla Alessandra Scorza; Esper Abrão Cavalheiro
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-11-18
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  33     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-31     Citation Subset:  IM    
Departamento de Fisiologia, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), Rua Botucatú 862, Ed. Ciências Biomédicas 5(0) andar, CEP 04023-900 São Paulo, Brazil.
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MeSH Terms
Brain / physiopathology
Disease Models, Animal
Epilepsy, Temporal Lobe / prevention & control,  therapy*
Motor Activity / physiology*
Neurodegenerative Diseases / therapy
Neuronal Plasticity / physiology
Neurons / physiology
Physical Conditioning, Animal*

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