| The phylogeny of central chemoreception. | |
| | |
MedLine Citation:
|
PMID: 20594933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Respiratory chemoreceptors responsive to changes in CO(2)/H(+) appear to be present in all vertebrates from fish to birds and mammals. They appear to have arisen first in the periphery sensitive to the external environment. Thus, in most fish CO(2)/H(+) chemoreceptors reside primarily in the gills and respond to changes in aquatic rather than arterial P(CO)₂ . In the air-breathing tetrapods (amphibians, mammals, reptiles and birds), the branchial arches regress developmentally and the derivatives of the branchial arteries are now exclusively internal. The receptors associated with these arteries now sense only arterial (not environmental) P(CO)₂/pH . Central CO(2)/H(+) chemoreception also appears to have arisen with the advent of air breathing, presumably as a second line of defense. These receptors may have arisen multiple times in association with several (but not all) of the independent origins of air breathing in fishes. There is strong evidence for multiple central sites of CO(2)/H(+) sensing, at least in amphibians and mammals, suggesting that it may not only have originated multiple times in different species but also multiple times within a single species. |
| | |
Authors:
|
W K Milsom |
Related Documents
:
|
6419753 - Deadspace and the single breath test for carbon dioxide during anaesthesia and artifici... 15228893 - Headache and facial pain in scuba divers. 9172123 - Successful pregnancy after bilateral hypogastric artery ligation. a case report. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-02 |
Journal Detail:
|
Title: Respiratory physiology & neurobiology Volume: 173 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-27 Completed Date: 2011-01-25 Revised Date: 2011-02-14 |
Medline Journal Info:
|
Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 195-200 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Zoology, University of British Columbia, Vancouver, BC, Canada. milsom@zoology.ubc.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carbon Dioxide / blood* Chemoreceptor Cells / physiology* Humans Oxygen / blood* Phylogeny* Respiratory Physiological Processes* |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mesenchymal stem cells reduce inflammation in a rat model of obstructive sleep apnea.
Next Document: Molecular simulations of carbohydrates and protein-carbohydrate interactions: motivation, issues and...