Document Detail

A photometric analysis of tablet movement in a side-vented perforated drum (Accela-Cota).
MedLine Citation:
PMID:  2858522     Owner:  NLM     Status:  MEDLINE    
A novel particle tracing technique has been used to study the effect of the normal process variables i.e. drum speed, drum loading and the presence/absence of mixing elements (baffles) on the movement of tablets in a side-vented perforated drum (24 in diameter Accela-Cota). The technique involves measuring the duration of light emission from a single luminous tablet using a photomultiplier mounted to scan the same area as a spray gun, and has enabled the quantification of both the time that the tablet spends on the surface per pass (surface time) and the time that the tablet spends within the bulk of the tablet bed (circulation time) over run lengths equating to the normal tablet coating cycle. The technique also allows the study of the uniformity of tablet appearances by means of circulation profiles. It was found that, while both the surface and circulation times decreased with increasing drum speed and loading, there was irregularity of tablet appearance especially at low drum speeds and in the absence of baffles.
T M Leaver; H D Shannon; R C Rowe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  37     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
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MeSH Terms
Technology, Pharmaceutical*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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