| Is photodynamic therapy a solution for keloid? | |
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MedLine Citation:
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PMID: 22095178 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Keloid is a common skin condition, especially in people of Asian and African decent. The treatment of keloid is still unsatisfactory. Photodynamic therapy (PDT) is a novel treatment for this condition, but is widely used in treating certain skin pre-malignant and malignant lesions due to its high efficiency and safety. Another aspect of PDT is its scarless (or minimal scarring) wound healing after treatment despite the fact that it causes skin inflammation. There are a few independent reports that indicate 5-aminolevulinic acid (ALA) or methylaminolevulinate (MAL)-PDT may be effective in keloid and hypertrophic scars. The mechanism is largely unknown. PDT may exert these effects by acting on keratinocytes and fibroblasts or directly on collagen/extracellular matrix (ECM) in keloid tissues, by inducing keloid fibroblast apoptosis/necrosis, modulating growth factor and cytokine expression, reducing collagen/ECM synthesis and causing degeneration of formed collagen/ECM. These potential mechanisms and the scope for topical PDT of keloids are considered in this article. |
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Authors:
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Z Nie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia Volume: 146 ISSN: 0026-4741 ISO Abbreviation: G Ital Dermatol Venereol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102852 Medline TA: G Ital Dermatol Venereol Country: Italy |
Other Details:
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Languages: eng Pagination: 463-72 Citation Subset: IM |
Affiliation:
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Photobiology Unit, Dermatology Centre, Inflammation Sciences Research Group, University of Manchester, Manchester Academic, Health Sciences Centre, Salford Royal NHS Trust, Manchester, UK - Zhuxiang.nie@manchester.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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