| The photodynamic effect: the comparison of chemiexcitation by luminol and phthalhydrazide. | |
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MedLine Citation:
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PMID: 20853519 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The presence of light, oxygen and photosensitizer (organic dye) is required for the photodynamic effect. Light and photosensitizer are harmless by themselves, but when combined with oxygen, reactive oxygen species (ROS) can be produced. This photodynamic effect is used in photodynamic therapy (PDT); the production of ROS as lethal cytotoxic agents can inactivate tumor cells. However, during PDT, there are many difficulties, so it is not possible to excite the photosensitizer using a laser, a source of light at the wavelengths specific to the photosensitizer (in visible region of the spectrum). Chemiluminescence is the light emission as a result of a chemical reaction. It is possible to use a chemiluminescent mixture to excite the photosensitizer even if the light emission does not conform to the absorption maximum of the photosensitizer. Luciferin and luminol have been used as chemiluminescent compounds (energizers) for the excitation of the photosensitizers. The aim of this work was to compare the chemiexcitation of some selected photosensitizers (e.g. fluorescein, eosin, methylene blue, hypericin and phthalocyanines) by chemiluminescent mixtures containing luminol (high chemiluminescent quantum yield) or phthalhydrazide (low chemiluminescent quantum yield) on some Gram-positive (Enterococcus faecalis, Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, E. coli) bacteria and some cell lines (NIH3T3 and MCF7). The efficiency of the chemiexcitation was dependent on the kind of the photosensitizer and on the type of the bacterial strain or cell line and was independent of the energizers. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Martina Bancirova; Jan Lasovský |
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Publication Detail:
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Type: Journal Article Date: 2010-09-20 |
Journal Detail:
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Title: Luminescence : the journal of biological and chemical luminescence Volume: 26 ISSN: 1522-7243 ISO Abbreviation: Luminescence Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100889025 Medline TA: Luminescence Country: England |
Other Details:
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Languages: eng Pagination: 410-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Physical Chemistry, Palacký University, Olomouc 771 46, Czech Republic. martina.bancirova@upol.cz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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