Document Detail


A photochemical approach for controlled drug release in targeted drug delivery.
MedLine Citation:
PMID:  22225916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Photochemistry provides a unique mechanism that enables the active control of drug release in cancer-targeting drug delivery. This study investigates the light-mediated release of methotrexate, an anticancer drug, using a photocleavable linker strategy based on o-nitrobenzyl protection. We evaluated two types of the o-nitrobenzyl-linked methotrexate for the drug release study and further extended the study to a fifth-generation poly(amidoamine) dendrimer carrier covalently conjugated with methotrexate via the o-nitrobenzyl linker. We performed the drug release studies by using a combination of three standard analytical methods that include UV/vis spectrometry, (1)H NMR spectroscopy, and anal. HPLC. This article reports that methotrexate is released by the photochemical mechanism in an actively controlled manner. The rate of the drug release varies in response to multiple control parameters, including linker design, light wavelength, exposure time, and the pH of the medium where the drug release occurs.
Authors:
Seok Ki Choi; Manisha Verma; Justin Silpe; Ryan E Moody; Kenny Tang; Jeffrey J Hanson; James R Baker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-20
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  20     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-26     Completed Date:  2012-05-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1281-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA. skchoi@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / administration & dosage*,  chemistry
Delayed-Action Preparations / chemistry*
Dendrimers / chemistry*
Methotrexate / administration & dosage*,  chemistry
Nitrobenzenes / chemistry*
Photolysis*
Grant Support
ID/Acronym/Agency:
1 R01 CA119409/CA/NCI NIH HHS; R01 CA119409-04/CA/NCI NIH HHS; R01 CA119409-04S1/CA/NCI NIH HHS; R01 CA119409-05/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Delayed-Action Preparations; 0/Dendrimers; 0/Nitrobenzenes; 0/PAMAM Starburst; 59-05-2/Methotrexate; E57JCN6SSY/nitrobenzene
Comments/Corrections

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