Document Detail

The phenylalanine loading test in the differential diagnosis of dystonia.
MedLine Citation:
PMID:  12601115     Owner:  NLM     Status:  MEDLINE    
Early diagnosis of dopa-responsive dystonia (DRD) and its delineation from other dystonic syndromes is of great relevance because DRD is an eminently treatable condition. The possible relevance of the phenylalanine loading test (Phe-L) in differentiating DRD from primary focal and generalized dystonia was investigated. A marked difference in the phenylalanine/tyrosine ratio between patients with DRD and patients with other types of dystonia was observed. This indicates that Phe-L may be helpful in the differential diagnosis of dystonias.
O Bandmann; M Goertz; J Zschocke; G Deuschl; W Jost; H Hefter; U Müller; P Zöfel; G Hoffmann; W Oertel
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  60     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-25     Completed Date:  2004-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  700-2     Citation Subset:  AIM; IM    
Department of Neurology, Philipps-University Marburg, Germany.
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MeSH Terms
Administration, Oral
Diagnosis, Differential
Dystonia / diagnosis*,  drug therapy
Levodopa / therapeutic use
Middle Aged
Phenylalanine / administration & dosage,  blood,  diagnostic use*
Predictive Value of Tests
Reference Values
Sensitivity and Specificity
Time Factors
Tyrosine / blood
Reg. No./Substance:
0/Levodopa; 55520-40-6/Tyrosine; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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