Document Detail


A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF).
MedLine Citation:
PMID:  23330839     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Panobinostat (LBH589), a novel histone deacetylase inhibitor (HDACi), was evaluated in a phase I study of patients with primary myelofibrosis (PMF) and post-essential thrombocythaemia/polycythaemia vera-related myelofibrosis (Post-ET/PV MF). Eighteen patients (PMF 56%; Post-PV MF 28%; Post-ET MF 17%) were treated in three cohorts at oral doses of (i) 20, (ii) 30, and (iii) 25 mg three times weekly consecutively. Reversible thrombocytopenia was the dose-limiting toxicity. Five patients (two in Dose Cohort 1, one in Dose Cohort 2 and two in Dose Cohort 3) received six or more cycles and were evaluable for response assessment. After the sixth cycle, three of these five patients achieved clinical improvement (CI) with 100% reduction in palpable splenomegaly from baseline, and two patients experienced stable disease. Panobinostat therapy was also associated with improvement in the degree of anaemia in two of the five patients. Of the three patients who achieved CI after six cycles, one patient achieved a near complete remission after 15 cycles of treatment and another patient had resolution of marrow fibrosis after 16 cycles. We conclude that panobinostat is a well-tolerated, clinically active treatment for MF patients, regardless of JAK2 V617F status, and most effective when given at low doses over long periods of time.
Authors:
John Mascarenhas; Min Lu; Timmy Li; Bruce Petersen; Tsivia Hochman; Vesna Najfeld; Judith D Goldberg; Ronald Hoffman
Related Documents :
22014849 - Use of anticoagulants in elderly patients.
11159239 - How much are patients willing to pay to avoid postoperative nausea and vomiting?
24729689 - Treatment selection and experience in multiple sclerosis: survey of neurologists.
21747659 - Pacemaker extrusion in a severely demented patient. device reimplantation via the femor...
1764579 - Unnecessary arterial doppler examination of the legs. clinical decision rules may help?
23430859 - Long-term pharmacological management of phenylketonuria, including patients below the a...
16872119 - Promoting hydration in patients with dementia in healthcare settings.
23843569 - Laser acupuncture in treatment of childhood bronchial asthma.
9497859 - Neuronopathic forms of gaucher's disease.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  British journal of haematology     Volume:  -     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Affiliation:
Division of Hematology, Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Thiol-Disulfide Exchange in Signaling: Disulfide Bonds as a Switch.
Next Document:  Standing Hand-Assisted Laparoscopic Treatment of Left Dorsal Displacement of the Large Colon and Clo...