| A phase II trial of carboplatin, methotrexate and fluorouracil in fluorouracil-pretreated colorectal cancer. | |
| | |
MedLine Citation:
|
PMID: 9669653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
5-Fluorouracil and leucovorin combination is the most commonly applied chemotherapy treatment for colorectal cancer patients, both in the adjuvant setting and for advanced disease. Patients resistant or refractory to the 5-fluorouracil-leucovorin combination have been treated in this phase II trial with carboplatin plus methotrexate and fluorouracil in sequence. Twenty patients with measurable lesions from advanced colorectal cancer were entered in the trial. The treatment plan was carboplatin 300 mg/m2 day 1, methotrexate 40 mg/m2 day 1, fluorouracil 600 mg/m2 day 2, every 21 days. Two patients with liver metastasis had a partial response. Median survival was 12 months (range 4-24). Toxicity was acceptable and no patient had to be hospitalized because of the treatment. In this set of patients activity of the new combination is marginal. |
| | |
Authors:
|
P Pronzato; F Botto; E Ghio; F Pensa; A Tognoni; F Vaira; A Vigani; E Neri |
Related Documents
:
|
1530533 - Failure of intensive chemotherapy in poor prognosis non-hodgkin's lymphoma. 861963 - Pilot study of two adriamycin-based regimens in patients with advanced malignant lympho... 12792983 - Changes in hemopoietic precursors after treatment of low-risk myelodysplasia with amifo... |
Publication Detail:
|
Type: Clinical Trial; Clinical Trial, Phase II; Journal Article |
Journal Detail:
|
Title: Journal of chemotherapy (Florence, Italy) Volume: 10 ISSN: 1120-009X ISO Abbreviation: J Chemother Publication Date: 1998 Jun |
Date Detail:
|
Created Date: 1998-09-18 Completed Date: 1998-09-18 Revised Date: 2009-08-04 |
Medline Journal Info:
|
Nlm Unique ID: 8907348 Medline TA: J Chemother Country: ITALY |
Other Details:
|
Languages: eng Pagination: 254-7 Citation Subset: IM |
Affiliation:
|
Dept of Medical Oncology, Ospedale S. Andrea, La Spezia, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use* Carboplatin / administration & dosage Colorectal Neoplasms / drug therapy* Drug Administration Schedule Female Fluorouracil / administration & dosage Humans Male Methotrexate / administration & dosage Middle Aged Salvage Therapy |
| Chemical | |
Reg. No./Substance:
|
41575-94-4/Carboplatin; 51-21-8/Fluorouracil; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Perioperative antibiotic prophylaxis in abdominal surgery for hernia repair: retrospective study of ...
Next Document: 5-Fluorouracil, high-dose folinic acid and mitomycin C combination chemotherapy in previously treate...