Document Detail


A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts.
MedLine Citation:
PMID:  7139848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prednimustine, an ester of chlorambucil and prednisolone, was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis. Disease subsets consisted of patients with acute non-lymphocytic leukemia (ANLL) over age 60; ANLL refractory to standard therapy; smouldering leukemia; and refractory anemia with excess blasts (RAEB). In agreement with previous studies, toxicity from Prednimustine was relatively mild, consisting primarily of infrequent myelosuppression, gastrointestinal side-effects, and mild hyperglycemia. This study did not, however, confirm previously reported remission rates in ANLL: in 41 evaluable patients only two complete remissions were achieved. Both occurred in the subset of patients with smouldering leukemia. We conclude that Prednimustine has limited activity in this patient population.
Authors:
D R Gandara; C A Ries; S A Schiff; C B George; J P Lewis; M M Koretz; S K Carter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer chemotherapy and pharmacology     Volume:  9     ISSN:  0344-5704     ISO Abbreviation:  Cancer Chemother. Pharmacol.     Publication Date:  1982  
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806519     Medline TA:  Cancer Chemother Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  10-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Anemia, Aplastic / blood,  drug therapy*
Chlorambucil / analogs & derivatives*
Drug Evaluation
Female
Humans
Leukemia / drug therapy*
Male
Middle Aged
Prednimustine / administration & dosage,  adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
29069-24-7/Prednimustine; 305-03-3/Chlorambucil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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