| A phase 1 study to evaluate dolutegravir's effect on renal function via measurement of iohexol and para-aminohippurate clearance in healthy subjects. | |
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MedLine Citation:
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PMID: 22905856 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: We aimed to explore associations between drugs dispensed to the father prior to conception and pregnancy outcomes such as preterm birth, perinatal mortality, foetal growth retardation and birth defects. METHODS: In this cohort study, two population-based registries, the Medical Birth Registry of Norway and the Norwegian Prescription Database, were linked. The study cohort consisted of 340,000 pregnancies in 2004-10. The association between specific drugs dispensed to the fathers during the last three months prior to conception and pregnancy outcomes were explored by estimating odds ratios (ORs) using multivariate logistic regression. RESULTS: About one quarter (26%) of the fathers were dispensed at least one drug during the last three months prior to conception, and 1.3% were dispensed at least one drug requiring special attention. Overall, the odds of different adverse pregnancy outcomes were not increased when the father had been dispensed drugs, i.e. the OR and confidence intervals (CIs) for any birth defect when the fathers had been dispensed any drug were 0.99 (0.94-1.0). When the fathers had been dispensed diazepam we found increased risk of perinatal mortality and growth retardation, with OR and CIs of 2.2 (1.2-3.9) and 1.4 (1.2-1.6), respectively. CONCLUSIONS: Large studies are necessary to reveal increased risk of rare outcomes as specific birth defects. Our study did not indicate that paternal drug exposure is an important risk factor for adverse pregnancy outcomes. |
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Authors:
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J Koteff; J Borland; S Chen; I Song; A Peppercorn; T Koshiba; C Cannon; H Muste; S C Piscitelli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-20 |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: - ISSN: 1365-2125 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 ViiV Healthcare. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society. |
Affiliation:
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ViiV Healthcare, Research Triangle Park, North Carolina, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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