Document Detail

The pharmacology of new ethylenediamine derivatives (ROM-126, ROM-131, MK-142) with antiarrhythmic action. Part I. General pharmacological properties.
MedLine Citation:
PMID:  241067     Owner:  NLM     Status:  MEDLINE    
Mentioned compounds, studied on several species of animals, decrease blood pressure and the heart rate, modify catecholamine-induced effects, show properties characteristic for the beta-receptor blocking agents. The stated differences being due mainly to the power of their action. These compounds possess also spasmolytic and locally anaesthetic action of various degrees. Only ROM-131 has antihistamine action.
K Ernest
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Polish journal of pharmacology and pharmacy     Volume:  27     ISSN:  0301-0244     ISO Abbreviation:  Pol J Pharmacol Pharm     Publication Date:    1975 Jul-Aug
Date Detail:
Created Date:  1975-12-11     Completed Date:  1975-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366561     Medline TA:  Pol J Pharmacol Pharm     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  363-79     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Anesthetics, Local
Anti-Arrhythmia Agents*
Blood Pressure / drug effects
Depression, Chemical
Dose-Response Relationship, Drug
Ethylenediamines / pharmacology*
Guinea Pigs
Heart Rate / drug effects
Histamine H1 Antagonists / pharmacology
Lethal Dose 50
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Nictitating Membrane / drug effects
Parasympatholytics / pharmacology
Respiration / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anesthetics, Local; 0/Anti-Arrhythmia Agents; 0/Ethylenediamines; 0/Histamine H1 Antagonists; 0/Parasympatholytics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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