| The pharmacology of local anesthetics--a review of the literature. | |
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MedLine Citation:
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PMID: 1371945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the nineteenth century, some natives of Peru noticed circumoral numbness, euphoria and analgesia after chewing the leaves of the Erythroxylen coca bush. By 1850, cocaine was isolated from the plant, marking the start of the local anesthetic era in clinical medicine. Over the past 50 years, many synthetic local anesthetics have been developed which have fewer side effects, increased specificity of action and a wider margin of safety than cocaine. Currently, local anesthetics are used topically, for local infiltration; and intravenously, for peripheral nerve blockade, for sympathetic blockade, as well as for epidural and intrathecal use. Although the route of administration may affect pharmacokinetics and pharmacodynamics, it is the purpose of this article to review the general pharmacology of this entire range of clinically useful compounds. |
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Authors:
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E R Young; T A MacKenzie |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal (Canadian Dental Association) Volume: 58 ISSN: 0709-8936 ISO Abbreviation: J Can Dent Assoc Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-04-16 Completed Date: 1992-04-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7907605 Medline TA: J Can Dent Assoc Country: CANADA |
Other Details:
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Languages: eng Pagination: 34-42 Citation Subset: D; IM |
Affiliation:
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Faculty of Dentistry, University of Toronto. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amides Anesthetics, Local / adverse effects, chemistry, pharmacology* Esters Heart Conduction System / drug effects Humans Ion Channels / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Anesthetics, Local; 0/Esters; 0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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