Document Detail

The pharmacology of local anesthetics--a review of the literature.
MedLine Citation:
PMID:  1371945     Owner:  NLM     Status:  MEDLINE    
In the nineteenth century, some natives of Peru noticed circumoral numbness, euphoria and analgesia after chewing the leaves of the Erythroxylen coca bush. By 1850, cocaine was isolated from the plant, marking the start of the local anesthetic era in clinical medicine. Over the past 50 years, many synthetic local anesthetics have been developed which have fewer side effects, increased specificity of action and a wider margin of safety than cocaine. Currently, local anesthetics are used topically, for local infiltration; and intravenously, for peripheral nerve blockade, for sympathetic blockade, as well as for epidural and intrathecal use. Although the route of administration may affect pharmacokinetics and pharmacodynamics, it is the purpose of this article to review the general pharmacology of this entire range of clinically useful compounds.
E R Young; T A MacKenzie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal (Canadian Dental Association)     Volume:  58     ISSN:  0709-8936     ISO Abbreviation:  J Can Dent Assoc     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-16     Completed Date:  1992-04-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7907605     Medline TA:  J Can Dent Assoc     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  34-42     Citation Subset:  D; IM    
Faculty of Dentistry, University of Toronto.
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MeSH Terms
Anesthetics, Local / adverse effects,  chemistry,  pharmacology*
Heart Conduction System / drug effects
Ion Channels / drug effects
Reg. No./Substance:
0/Amides; 0/Anesthetics, Local; 0/Esters; 0/Ion Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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