| The pharmacology of human appetite expression. | |
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MedLine Citation:
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PMID: 15058309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The discovery of the adiposity signal leptin a decade ago revolutionised our understanding of the hypothalamic mechanisms underpinning the central control of ingestive behaviour. Subsequently, the structure and function of various hypothalamic peptide systems (Neuropeptide Y (NPY), Orexins, Melanocortins, Cocaine and Amphetamine Regulating Transcript (CART), Galanin/Galanin Like Peptides (GALP) and endocannabinoids) have been characterised in detail in rodent models. The therapeutic benefit of targeting these systems remains to be discovered. More is becoming known about the pharmacological potential of peripheral, meal-induced, episodic endogenous peptides. Hormones such as Cholecystokinin (CCK), Gastrin Releasing Peptides (GRP), Glucagon-Like Peptide I (GLP-1) Enterostatin, Amylin, Peptide YY (PYY) and Ghrelin are released prior to, during and/or after a meal, controlling intake and subjective feelings of appetite (hunger and satiety). In addition, there is an expanding body of literature detailing the effects of a wide variety of drugs on human appetite and food intake. Some of these drugs act upon CNS monoamine systems such as Serotonin (5-HT). Dopamine (DA) and Noradrenaline (NA), have long been implicated in appetite regulation. Detailed examination of both the effect of agonising endogenous gut peptide systems and the effect of various monoaminergic drugs on the expression of human appetite can provide a greater understanding of mechanisms underpinning normal appetite regulation. However, such an understanding must be based on knowledge of the effect of the treatment on meal size, eating rate, meal pattern, food choice and the subjective experience of appetite flux (hunger and satiety), and notjust food intake. |
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Authors:
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Jason C G Halford; Gillian D Cooper; Terence M Dovey |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current drug targets Volume: 5 ISSN: 1389-4501 ISO Abbreviation: Curr Drug Targets Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-02 Completed Date: 2004-07-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 221-40 Citation Subset: IM |
Affiliation:
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Kissileff Laboratory for the Study of Human Ingestive Behaviour, Department of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, L69 7ZA, UK. j.c.g.halford@liv.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Appetite
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drug effects,
physiology Appetite Regulation / physiology* Clinical Trials as Topic Digestive System / metabolism Eating Gastrointestinal Hormones / metabolism Humans Hunger / physiology Hypothalamus / metabolism Neuropeptides / physiology Neurotransmitter Agents / physiology Pharmacology* Satiety Response / physiology |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Hormones; 0/Neuropeptides; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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