Document Detail

The pharmacological treatment of patent ductus arteriosus. A review of the evidence.
MedLine Citation:
PMID:  2670518     Owner:  NLM     Status:  MEDLINE    
Modern heart surgery began with operative intervention for patent ductus arteriosus in 1938. Half a century later, ligation and division of patent ductus arteriosus in an infant or child remains a simple and safe surgical procedure for a lesion identified relatively easily. In the intervening years, paediatric cardiologists and surgeons have also directed their attention to the management of more complex congenital cardiac defects. Recently, however, there has been a significant reappraisal and re-emphasis of the role of patent ductus arteriosus in the context of neonatal cardiopulmonary disease. Interest has focused on: (a) surgical and pharmacological management of the premature infant with a large ductal left-to-right shunt in the context of respiratory distress syndrome; (b) preservation of patency in ductal-dependent congenital heart disease; and (c) ductal right-to-left shunting in persistence of the fetal circulation (PFC) syndrome or other diseases associated with increased pulmonary vascular resistance. This review examines the above conditions and reviews the progress and current status of drug therapy in the treatment of these disorders. Closure of the ductus arteriosus with cyclo-oxygenase inhibition as well as re-opening and maintaining patency of the ductus arteriosus with prostaglandin therapy is discussed.
R J Barst; W M Gersony
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  38     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-05     Completed Date:  1989-10-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-66     Citation Subset:  IM    
College of Physicians and Surgeons of Columbia University, New York.
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MeSH Terms
Ductus Arteriosus, Patent / drug therapy*
Indomethacin / therapeutic use
Infant, Newborn
Reg. No./Substance:

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