Document Detail


The pharmacological profile of (-)deprenyl (selegiline) and its relevance for humans: a personal view.
MedLine Citation:
PMID:  1608919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
(-)Deprenyl (selegiline, jumex, eldepryl, movergan) which is closely related to phenylethylamine (PEA) is a drug with a unique pharmacological spectrum. Single dose effects: (a) It is a highly potent and selective inhibitor of B-type monoamine oxidase (MAO). (b) In contrast to other MAO inhibitors it inhibits the noradrenaline releasing effect of tyramine, is therefore free of the 'cheese effect'. Multiple dose effects unrelated to MAO inhibition: (a) It enhances superoxide dismutase and catalase activity in the striatum. (b) It facilitates the activity of the nigrostriatal dopaminergic neurones. (c) It prevents age-related morphological changes in the neurocytes of the substantia nigra. Consequences of multiple dose effects: Compared to salt solution-treated rats, male rats maintained on (-)deprenyl loose their capacity to ejaculate later on; retain for longer their learning ability; and live longer. Freshly diagnosed Parkinson's patients maintained on (-)deprenyl, required levodopa later than their placebo-treated peers. Patients treated with levodopa plus (-)deprenyl live longer than those on levodopa alone. Chronic treatment with (-)deprenyl improves the performance of patients with Alzheimer's disease.
Authors:
J Knoll
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  70     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-23     Completed Date:  1992-07-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  317-21     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy
Animals
Brain / drug effects
Humans
Parkinson Disease / drug therapy
Selegiline / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
14611-51-9/Selegiline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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