Document Detail


A pharmacological approach to gastric acid inhibition.
MedLine Citation:
PMID:  16335853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proton pump inhibitors have changed our approach to gastric acid-related diseases. They are much more potent acid inhibitors than H2-antagonists and exhibit a sophisticated mechanism of action. The present review analyses the general pharmacology of proton pump inhibitors and differentiates the specific characteristics of the various compounds that belong to this family. Special emphasis has been placed in describing the clinical implications of such differences and the potential importance for adverse effects.
Authors:
Juan V Esplugues
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  65 Suppl 1     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-12     Completed Date:  2005-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain. juan.v.esplugues@uv.es
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MeSH Terms
Descriptor/Qualifier:
Anti-Ulcer Agents / pharmacology*
Gastric Acid / secretion*
Humans
Peptic Ulcer / drug therapy*
Proton Pumps / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Proton Pumps

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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