Document Detail

A pharmacological analysis of food intake regulation in rats treated neonatally with monosodium L-glutamate (MSG).
MedLine Citation:
PMID:  2726997     Owner:  NLM     Status:  MEDLINE    
Studies were conducted to examine deficits in food intake regulation in MSG-treated rats that result from known or suspected damage to neurotransmitter systems involved in feeding. Male rats were injected with either MSG (4 mg/g) or sodium chloride on postnatal days 2 and 4 (MSG-Lo) or postnatal days 2, 4, 6 and 8 (MSG-Hi). As adults, MSG-treated and control rats (n = 12/group) were examined for deficits in pharmacologically elicited feeding and other measures of food intake regulation. A second group of MSG-treated (n = 9/group) and control rats (n = 12) were used to measure basal blood pressure and nociceptive reactivity in adulthood. Organ weights, body weight and neuropeptide Y (NPY) content in brain regions were determined at the end of the study. MSG-Hi rats consumed significantly less food than controls during the dark part of the light cycle. Both MSG-Hi and MSG-Lo groups ate significantly less food than controls after a 48-hour fast. MSG-Hi and MSG-Lo rats consumed significantly less food than controls in response to 1.0 mg/kg morphine. MSG-Hi rats consumed significantly less food than controls during the dark phase and significantly more food than controls during the light phase in response to naloxone (1.0 mg/kg). MSG-Lo ate significantly more than controls in response to 0.1 mg/kg guanfacine. MSG-Hi and MSG-Lo showed a significant attenuation in diazepam-stimulated feeding when compared to controls. Blood pressure was significantly lower in both MSG-Hi and MSG-Lo rats compared to controls. Tail flick latencies were not altered by MSG-treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
R Dawson; D R Wallace; S M Gabriel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  32     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-07-12     Completed Date:  1989-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-8     Citation Subset:  IM    
Department of Pharmacodynamics, College of Pharmacy University of Florida, Gainesville 32610.
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MeSH Terms
Animals, Newborn / physiology*
Blood Pressure / drug effects
Body Weight / drug effects
Dose-Response Relationship, Drug
Eating / drug effects*
Glutamates / toxicity*
Neuropeptides / pharmacology
Organ Size / drug effects
Rats, Inbred Strains
Reaction Time / drug effects
Sodium Glutamate / toxicity*
Yohimbine / pharmacology
Reg. No./Substance:
0/Glutamates; 0/Neuropeptides; 142-47-2/Sodium Glutamate; 146-48-5/Yohimbine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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