| A pharmacological analysis of food intake regulation in rats treated neonatally with monosodium L-glutamate (MSG). | |
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MedLine Citation:
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PMID: 2726997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were conducted to examine deficits in food intake regulation in MSG-treated rats that result from known or suspected damage to neurotransmitter systems involved in feeding. Male rats were injected with either MSG (4 mg/g) or sodium chloride on postnatal days 2 and 4 (MSG-Lo) or postnatal days 2, 4, 6 and 8 (MSG-Hi). As adults, MSG-treated and control rats (n = 12/group) were examined for deficits in pharmacologically elicited feeding and other measures of food intake regulation. A second group of MSG-treated (n = 9/group) and control rats (n = 12) were used to measure basal blood pressure and nociceptive reactivity in adulthood. Organ weights, body weight and neuropeptide Y (NPY) content in brain regions were determined at the end of the study. MSG-Hi rats consumed significantly less food than controls during the dark part of the light cycle. Both MSG-Hi and MSG-Lo groups ate significantly less food than controls after a 48-hour fast. MSG-Hi and MSG-Lo rats consumed significantly less food than controls in response to 1.0 mg/kg morphine. MSG-Hi rats consumed significantly less food than controls during the dark phase and significantly more food than controls during the light phase in response to naloxone (1.0 mg/kg). MSG-Lo ate significantly more than controls in response to 0.1 mg/kg guanfacine. MSG-Hi and MSG-Lo showed a significant attenuation in diazepam-stimulated feeding when compared to controls. Blood pressure was significantly lower in both MSG-Hi and MSG-Lo rats compared to controls. Tail flick latencies were not altered by MSG-treatment.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R Dawson; D R Wallace; S M Gabriel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 32 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-07-12 Completed Date: 1989-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 391-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, College of Pharmacy University of Florida, Gainesville 32610. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / physiology* Blood Pressure / drug effects Body Weight / drug effects Dose-Response Relationship, Drug Eating / drug effects* Female Glutamates / toxicity* Male Neuropeptides / pharmacology Organ Size / drug effects Pregnancy Rats Rats, Inbred Strains Reaction Time / drug effects Sodium Glutamate / toxicity* Yohimbine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Neuropeptides; 142-47-2/Sodium Glutamate; 146-48-5/Yohimbine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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