| The pharmacologic elegance of inhibiting cholesterol absorption and synthesis while providing a homeostatic balance. | |
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MedLine Citation:
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PMID: 18001316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The recent discoveries on the concerted role of several mechanisms involved in regulating the balance of body cholesterol highlight the role of intestinal absorption. Selective modulators of intestinal cholesterol absorption are available that offer a new pharmacologic approach to the modulation of total body cholesterol homeostasis and to a more effective reduction of low-density-lipoprotein cholesterol. |
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Authors:
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Alberico L Catapano |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 21 Suppl 2 ISSN: 0767-3981 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2008-03-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Affiliation:
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Center for the Study of Atherosclerosis and Laboratory of Lipoprotein Metabolism, Department of Pharmacological Sciences, University of Milan, Milan, Italy. alberico.catapano@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / pharmacology*, therapeutic use Azetidines / pharmacology, therapeutic use Cholesterol / biosynthesis, metabolism*, pharmacokinetics Homeostasis / drug effects* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology, therapeutic use Hypercholesterolemia / drug therapy, metabolism Intestinal Absorption / drug effects Liver / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Azetidines; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 163222-33-1/ezetimibe; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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