| The pharmacokinetics of taurolidine metabolites in healthy volunteers. | |
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MedLine Citation:
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PMID: 17395893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Taurolidine is an experimental antibacterial and antiendotoxic compound whose clinical utility as an antitumor agent is being investigated in human clinical trials. Taurolidine in aqueous solution exists in equilibrium with taurultam. Taurultam is subsequently transformed to taurinamide. The pharmacokinetic profiles of these metabolites are not well established. In this study, 18 healthy volunteers were administered 5.0 g of taurolidine in 250 mL of 5% polyvinylpyrrolidone in water over 2, 1, or 0.5 hours by intravenous infusion in a parallel-group design. All subjects noted discomfort at the infusion site, although there were no serious adverse events. t(max) generally occurred at the end of infusion for taurinamide, whereas that of taurultam was reached before completion of infusion. The taurolidine metabolite taurultam demonstrated a shorter half-life and lower systemic exposure than taurinamide. Shortening of infusion duration increased the C(max) and AUC of taurultam. Changes in infusion rate did not substantially change the pharmacokinetic parameters of taurinamide. |
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Authors:
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Li Gong; Howard E Greenberg; James L Perhach; Scott A Waldman; Walter K Kraft |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-03-29 |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 47 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-23 Completed Date: 2007-07-24 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 697-703 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Experimental Therapeutics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents / administration & dosage, blood, pharmacokinetics* Area Under Curve Drug Administration Schedule Female Half-Life Humans Male Pharmaceutic Aids Povidone Taurine / administration & dosage, analogs & derivatives*, blood, pharmacokinetics Thiadiazines / administration & dosage, blood, pharmacokinetics* |
| Grant Support | |
ID/Acronym/Agency:
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5 T32 GM008562-11/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Pharmaceutic Aids; 0/Thiadiazines; 107-35-7/Taurine; 19388-87-5/taurolidine; 9003-39-8/Povidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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