Document Detail


The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals.
MedLine Citation:
PMID:  23407222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Isoniazid preventive therapy (IPT) is recommended in patients on antiretroviral treatment. Isoniazid (INH) inhibits CYP3A4, which metabolises nevirapine (NVP). Administration of INH may cause higher NVP concentrations and toxicity. We studied the effect of INH on NVP concentrations in 21 patients randomised to either placebo (n = 13) or INH (n = 8) in an ongoing trial of IPT in patients on ART. INH was associated with a 24% increase in median NVP area under the plasma concentration-time curve for the 12 h dosing interval, which was not statistically significant (P = 0.66).
Authors:
E H Decloedt; J Mwansa-Kambafwile; J-S van der Walt; H McIlleron; P Denti; P Smith; L Wiesner; M Rangaka; R J Wilkinson; G Maartens
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  17     ISSN:  1815-7920     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-07-26     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  333-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-HIV Agents / administration & dosage,  blood,  pharmacokinetics*
Antitubercular Agents / administration & dosage*
Area Under Curve
Biotransformation
Cytochrome P-450 CYP3A / antagonists & inhibitors*,  metabolism
Drug Administration Schedule
Drug Interactions
Drug Monitoring
Enzyme Inhibitors / administration & dosage*
Female
HIV Infections / drug therapy*
Humans
Isoniazid / administration & dosage*
Male
Nevirapine / administration & dosage,  blood,  pharmacokinetics*
South Africa
Grant Support
ID/Acronym/Agency:
084323//Wellcome Trust; 088316//Wellcome Trust; 5U2 RTW007373//PHS HHS; U.1175.02.002.00014.01//Medical Research Council; U2RTW007370/3//PHS HHS; U2RTW007373//PHS HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Antitubercular Agents; 0/Enzyme Inhibitors; 99DK7FVK1H/Nevirapine; EC 1.14.13.67/CYP3A4 protein, human; EC 1.14.14.1/Cytochrome P-450 CYP3A; V83O1VOZ8L/Isoniazid
Comments/Corrections

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