Document Detail

The pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion.
MedLine Citation:
PMID:  16781256     Owner:  NLM     Status:  MEDLINE    
Misoprostol is a synthetic prostaglandin E(1) analogue that is commonly used for medical abortion. It can be given orally, vaginally and sublingually. A pharmacokinetic study has shown that sublingual misoprostol has the shortest onset of action, the highest peak concentration and the greatest bioavailability among the three routes of administration. Earlier clinical trials have shown that vaginal misoprostol is superior to oral misoprostol when combined with mifepristone for early first-trimester medical abortion. Recent studies on the clinical efficacy of sublingual misoprostol have demonstrated that it is as effective as vaginal misoprostol. Further studies are required to determine the optimal dose and route of administration of misoprostol that can give the highest complete abortion rate, lowest ongoing pregnancy rate and least side effects.
Oi Shan Tang; Pak Chung Ho
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-27
Journal Detail:
Title:  Contraception     Volume:  74     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, People's Republic of China.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*,  pharmacokinetics*
Abortion, Induced / methods*
Administration, Intravaginal
Administration, Oral
Administration, Sublingual
Gestational Age*
Misoprostol / administration & dosage*,  chemistry,  pharmacokinetics*
Pregnancy Trimester, First
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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