| The pharmacokinetics of clofoctol in healthy neonates and adults studied by an original HPLC technique. | |
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MedLine Citation:
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PMID: 6652171 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics of clofoctol [(tetramethyl-1,1,3,3,butyl)-4-(dichloro-2,4-benzyl)-2-hydroxy-1-benzene ] was investigated in six healthy newborns and compared with the kinetic parameters of the drug in six healthy adults. The concentration of the drug in plasma was measured by means of an original sensitive HPLC technique. In both neonates and adults treated rectally with clofoctol, the plasmatic peak occurred at the 30th min, although the maximal peak of adults was significantly lower. Kel and T1/2 exhibited a similar pattern, whereas the AUC was about 5 times higher in newborns. The present findings suggest that clofoctol is well absorbed rectally. The higher plasmatic levels of clofoctol in neonates may result from their lower degree of hepatic metabolic activity. |
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Authors:
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M del Tacca; M Ducci; G Soldani; A Boldrini; M Fantoni; A Bertelli |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Biological research in pregnancy and perinatology Volume: 4 ISSN: 0724-438X ISO Abbreviation: Biol Res Pregnancy Perinatol Publication Date: 1983 |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302758 Medline TA: Biol Res Pregnancy Perinatol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 166-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents / blood, metabolism* Chromatography, High Pressure Liquid Cresols / blood, metabolism Humans Infant, Newborn Kinetics Male Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Cresols; 37693-01-9/clofoctol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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