Document Detail


The pharmacokinetics of bumetanide in the newborn infant.
MedLine Citation:
PMID:  9395836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study characterizes the pharmacokinetics of bumetanide after an intravenous dose of 0.05 or 0.10 mg/kg to 14 neonates (weight range 820-4,000 g; gestational age 26-40 weeks) during the first week of life. Blood samples and urine were collected for up to 12 h after dosing. Estimated serum clearance was 0.2-1.0 ml/min.kg (range), volume of distribution was 0.22 l/kg (range 0.11-0.32 l/kg), and the harmonic mean half-life was 6-7 h (range of 4-19 h). Nonrenal clearance accounted for 58-97% of the serum clearance with the presence of certain oxidative metabolites of bumetanide in the urine. These findings suggest higher dosing requirements and prolonged intervals as compared to adults. Utilizing these pharmacokinetic data, pharmacodynamic and ototoxicity studies should be conducted to establish a safe and effective neonatal dose.
Authors:
A M Lopez-Samblas; J A Adams; R N Goldberg; M W Modi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  72     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1997  
Date Detail:
Created Date:  1998-02-03     Completed Date:  1998-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  265-72     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Miami School of Medicine, Fla., USA.
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MeSH Terms
Descriptor/Qualifier:
Bumetanide / administration & dosage,  blood,  pharmacokinetics*,  urine
Diuretics / administration & dosage,  blood,  pharmacokinetics*,  urine
Humans
Infant, Newborn / blood,  metabolism*,  urine
Injections, Intravenous
Time Factors
Chemical
Reg. No./Substance:
0/Diuretics; 28395-03-1/Bumetanide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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